IT Leadership Jobs in San Francisco

14 open it leadership jobs in San Francisco, CA, as of Sep 25, 2026. Of the 14 newest, 3 are remote or hybrid and 2 list a salary. Hiring most: Anthropic, Business Wire and Matter Intelligence. Every listing comes from the employer’s own hiring system.

Plus 28 remote it leadership jobs open to people anywhere in the US.

Sr. IT Program Manager, Helen Diller HospitalNew
Company
San Francisco, California
Associate Chief Information Officer Education ITNew
Company
San Francisco, California
Senior Manager, IT SOX3d
Anthropic
San Francisco, California
General Manager, IT Operations9d
Business Wire
San Francisco, California · Hybrid
Head of IT and Security10d
Matter Intelligence
San Francisco, California · On-site
Director, IT Operations2w
Instacart
San Francisco, California · Remote
Chief Information Security Officer3w
Zipline
South San Francisco, California
Head of IT5w
Magic
San Francisco, California · On-site · US$200,000–350,000 / year
Chief Information Security Officer5w
Trustly
San Francisco, California · On-site · US$350,000–470,000 / year
Senior Manager, IT Enterprise Applications - People & Legal6w
BridgeBio Pharma
San Francisco, California
Head of IT & Security6w
NexHealth
San Francisco, California
Senior Product Manager, IT Finance7w
Salesforce
San Francisco, California · On-site
Senior Manager, IT7w
Lattice
San Francisco, California · Remote
Vice President & Chief Information Security Officer3mo
Planet
San Francisco, California
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